The determination of regular blood pressure and electrolyte levels is essential for the first few months of treatment. It can be dangerous to use Spironolactone in moderate renal impairment.
It acts as an androgen antagonist by inhibiting androgen receptors, as well as the production of androgens from the ovaries. The user should not exceed 100-200mg / day doses. It also has different side effects than other anti-androgens such as postural hypotension and electrolyte disorders. Furthermore, menstrual disorders, weakness, urticaria, breast tenderness, and haematological disorders are other possible side effects.
Spironolactone Negative Effect
Research shows that the use of spironolactone has little effect on stopping hair loss and restoring hair. Unfortunately, a dose causes an increase in potassium levels, which means the risk of hyperkalaemia and other side effects, including cramping and diarrhoea.
Diuretics can also affect blood potassium levels. If you take a potassium-sparing diuretic, you can develop too much potassium (hyperkalemia). On the other hand, if you use thiazide diuretics, you can develop very little potassium (hypokalemia).
Diuretics are generally safe but have some side effects, such as constant urination and loss of minerals. This may lead to hair loss as our hair needs necessary minerals and nutritions for continual growth. Therefore, spironolactone may have a negative effect on hair as well.
Spironolactone Positive Effect
Spironolactone is a common treatment of polycystic ovarian syndrome and hirsutism cases in women. Besides, it is a potassium-sparing diuretic. Therefore it reduces fluid in the body without causing potassium loss. It is also for the treatment of cirrhosis cases of ascites.
Spironolactone has anti-androgenic effects. Therefore, it is possible to use it in the treatment of hair loss in women. The binding of these androgens reduces weakly resistant cellular receptors and testosterone synthesis.
Spironolactone acts as an anti-androgen in two ways. First, it slows down the androgen production of the adrenal glands and ovaries. Second, it blocks the conversion of testosterone to dihydrotestosterone (DHT). Spironolactone is one of the most potent anti-androgen drugs. It is preferred for topical treatments since it does not pass into the systemic circulation.